Spok - Stei
- Spokan
- Spokane
- Spokane Plain, Battle of
- Spokane Plains, Battle of
- Spokane Reservation
- Spokane River
- Spokane Stock Exchange
- Spokane, Mount
- spook
- Spoon River
- Spoon River Anthology
- sport utility vehicle
- Sporter
- Sports Car Club of America Inc.
- Sports Illustrated
- spot
- spot ad
- Spotswood, Alexander
- Spotsylvania Court House, Battle of
- spotted sandpiper
- spotted skunk
- Spotted Tail
- spouse abuse
- Sprague, Frank Julian
- Spray 'n Wash
- spread
- spread eagle
- Spreckels, Claus (Sugar King)
- Springer Mountain
- Springfield
- Springfield Armory National Historic Site
- Springfield rifle
- Springsteen, Bruce
- Sprinkel, Beryl Wayne
- Sprint
- Sprint Communications Co.
- Sprite
- Spruance, Raymond Ames
- Spruce Knob
- Spud State
